References for: Causes, evaluation, and treatment.
Medscape Women’s Health 1998 May;3(3):2 (ISSN: 1521-2076) Bick RL; Madden J; Heller KB; Toofanian A
Thrombosis Clinical Center, Department of Medicine (Hematology & Oncology), Presbyterian Hospital of Dallas, Tex., USA.
Recurrent fetal loss associated with hemorrhagic disorders comes about due to interference with adequate fibrin formation, thereby disrupting implantation of the fertilized ovum into the uterine lining. The hemorrhagic defects associated with recurrent fetal loss include factor XIII, factor X, factor VII, factor V, and factor II (prothrombin) deficiencies, as well as fibrinogen defects including afibrinogenemia and those dysfibrinogenemias associated with hemorrhage. All of these defects are rare; management is generally plasma-substitution therapy.